Hippokratia 1998, 2(1):32-37

AP. Efthmiadis, N. Lefkos, F. Sugiultzoglou, I. Papadopoulos, G. Kazinakis, Ag. Mertzemekis, G. Tsapas

Abstract

Aim of the study is to stress the role of the effect of the CUD risk factors on the long-term prognosis of patients with experience on bypass surgery. Methods: 117 persons, middle aged, both sexes (M = 72, F = 45, mean age 48,5 ? 6,7), have been studied and divided in 4 groups. Group I: 20 healthy adults (M = 11, F = 9, mean age 33,1?6,8 years) who consist the control group. Group II: 21 patients (M = 15, F = 6, mean age 48,7?5,8 years) who were subjected to bypass surgery because of three vessel disease and they did not exhibit any complication two years after surgery (normal progress). Group III: 37 patients (M = 21, F = 16, mean age 55,6?5,8 years) who were hospitalized in our cardiology department for AMI during the first or the second year after the by pass operation. Group IV: 39 patients (M = 25, F = 19, mean age 56,9?11,5) who were hospitalized in our clinic for AMI, without by pass surgery. In all these patients the CHD risk factors blood glucose, serum lipids, and lipoprotein-a were defined. Also the haemostatic-fibrinolytic factors (fibrinogen, AT-III, PAI-1 and t-PA) were defined in all patients. Results: 1. Patients with bypass surgery consisted the 48% of the total number of patients who were hospitalized for AMI in our department during one year time. Significant increase of Lp(a), fibrinogen, LDL-x, PAI-1, t-PA and decrease of HDL-x and AT-III have been ascertained in patients of group III compared to those of control group and to those of group II (by pass surgery with normal progress). 2. Significant differences in the above parameters were not found out in patients with AMI regardless of by pass surgery. Conclusions: The accumulation of CHD risk factors and the disorders of heamostatic-fibrinolytric mechanisms define significantly the postoperative progress of the patients who experience the bypass surgery regardless of drug treatment for CHD.

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