Hippokratia 2016, 20(3):249-251

Koutouzis M1, Ziakas A2, Didagelos M2, Maniotis C1, Kyriakides Z1
1Cardiology Department, Red Cross General Hospital, Athens, 21st Cardiology Department, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece


Background: Switching to femoral after a failed radial approach carries an increased risk of bleeding complications since the femoral artery puncture is performed in patients already anticoagulated. Moreover, dedicated radial operators find it more and more difficult to use the femoral approach, and ulnar artery cannulation provides them with the opportunity to further reduce its use. Our objective was to evaluate the feasibility and safety of ipsilateral radial and ulnar artery cannulation during the same coronary catheterization procedure.
Methods: We performed a retrospective analysis of all cardiac catheterizations, from January 2015 until June 2016, with initial radial approach and conversion to ipsilateral ulnar approach. Patients with sheath insertion both in radial and ipsilateral ulnar arteries were further evaluated.
Results: Four thousand one hundred and two procedures were performed during the study period, and 3,876 (94.5 %) of them were performed initially through a radial approach. Radial and ipsilateral ulnar catheterization was accomplished in nine patients, resulting in successful catheterization and procedure completion, without any serious complications recorded.
Conclusions: Ipsilateral radial and ulnar artery catheterization proved to be feasible and safe, without any serious complications. Hippokratia 2016, 20(3): 249-251

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Key words: Transradial, transulnar, cardiac catheterization, radial artery catheterization, ipsilateral ulnar artery catheterization, coronary intervention

Corresponding author: Michael Koutouzis, MD, PhD, Red Cross General Hospital, 11526, Athens, Greece, tel: +302132068304, +306972321536, fax: +302132068084, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.



Transradial approach for cardiac catheterization is a word wide evolving technique since it results in less bleeding complications and less mortality in ST-segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PCI)1,2. Due to the possibility of radial artery occlusion after the procedure, a functional dual blood supply (from the radial and ulnar artery) of the hand was considered crucial before radial catheterization. However, recent evidence showed that even patients with a negative Allen’s test could be successfully and safely catheterized through the radial artery3. Dual sheath insertion (in radial and ipsilateral ulnar artery) is not a recommended practice and data on this strategy are limited4. In the present study we evaluated the feasibility and safety of this strategy.


Study sample

We performed a retrospective analysis of all patients who underwent cardiac catheterization in the Red Cross General Hospital during an 18-month period (January 2015 - June 2016). The initial approach, conversion to another approach and the alternative approach were all at operating physician’s discretion. All five operators were high volume operators (more than 300 cases per year) and experienced in transradial procedures (more than 80 % radial approach for all operators). Informed consent was obtained from all patients before the procedure. The study was approved by the institution’s Ethics committee (Red Cross General Hospital Scientific Committee, 32-02/12/2014).

Radial and ulnar artery cannulation

All radial and ulnar arteries were cannulated with the cannula over the needle technique, with a 20G plastic cannula. When optimal arterial “back flow” was obtained, a 0.025’’ guidewire was inserted, and a 5Fr or 6Fr introducer (SCW Medicath LTD, China or KDL, China) was inserted over the guidewire. The size of the introducer was at operating physician’s discretion. Switching to a larger introducer was performed by leaving the 0.035’’ guidewire in place to secure access to the ascending aorta, and a femoral introducer was inserted over the guidewire in the forearm artery. Unfractionated heparin (50-100 IU/Kgr, maximum 5,000 IU) and verapamil 5 mg were administered intra-sheath to avoid artery occlusion and spasm. Cannulation of the radial and the ipsilateral ulnar artery is shown in Figure 1.

Figure 1: Radial and ipsilateral ulnar artery cannulation of the right forearm.

Coronary angiography and intervention

Diagnostic procedures were performed with 5Fr catheters (Boston Scientific, Marlborough, Massachusetts, USA), while percutaneous coronary interventions were performed with 6Fr or 7Fr guiding catheters (Boston Scientific, Marlborough, Massachusetts, USA). The type of the guiding catheter, coronary guidewires, balloons, and stents were at operating physician’s discretion. Bivalirudin (0.75 mg/kg bolus and 1.75 mg/kg/h infusion until the end of the procedure) or unfractionated heparin intravenously (in order to achieve 100 IU/kg in total) was administered in PCI patients. Glycoprotein IIb-IIIa inhibitors were used as a bail-out therapy.


Hemostasis was achieved using a tourniquet based closure device (KDL, China) and patent hemostasis or ULTRA method facilitated patent hemostasis was aimed in all patients5. In the case of ipsilateral radial and ulnar artery cannulation during the same procedure, two devices were placed on the same wrist. The devices were gradually released and in most cases were withdrawn after 3-4 hours. The patency of the radial and ulnar artery was evaluated before patient’s discharge by radial artery palpation and Doppler or duplex ultrasonography.


Four thousand one hundred two patients were included in the analysis. Three thousand eight hundred seventy-six (94.5 %) of the procedures were performed with the radial approach as the primary operator’s choice. After sheath insertion, in 190 (4.9 %) patients successful completion of the procedure was not possible, and a conversion to another approach was necessary. The following approaches were chosen: femoral approach (56 patients, 29.5 %), contralateral radial (101, 53.2 %), contralateral ulnar (24, 12.6 %) and ipsilateral ulnar (9, 4.7 %).

Nine patients who had the radial and the ipsilateral ulnar artery cannulated during the same procedure were identified. None of them had a prior radial or ulnar artery catheterization. Patient characteristics, type of procedure, sheath size, cause of conversion, and procedure outcome are presented in Table 1. All nine patients had palpable and patent by ultrasound radial and ulnar arteries after closure device removal and no local ischemic complications. One patient suffered a mild forearm hematoma graded as type II according to the Early Discharge After Transradial Stenting of Coronary Arteries (EASY) classification, which resolved conservatively.


All radial and ipsilateral ulnar catheterizations were successfully accomplished, without the need to convert to a femoral approach. Switching to the femoral approach after a failed radial approach carries an increased risk of bleeding complications, since the femoral artery puncture is performed in patients already anticoagulated (after radial sheath insertion, heparin is always administered).

Agostoni et al have previously published the results of the SWITCH registry with six patients having a radial and ipsilateral ulnar artery simultaneous cannulation, without any reported ischemic complications4. Our data shed further light on this approach. It should be mentioned that the rate of radial approach in our cohort was much higher (94.5 % versus 66.5 %) and the rate of switching from the radial to another approach (4.9 % versus 6.9 %) was less.

Dedicated radial operators find it more and more difficult to use the femoral approach. This can be faced with two alternatives: either by increasing the transfemoral procedures in order to maintain their skills or by reducing it further in order to practically eliminate the possibility to use it. In our center, we apply the second alternative, as we maintain the femoral approach only as a final solution when all other forearm approaches are not feasible. We usually try this in the following order: right radial, left radial, right ulnar, left ulnar artery. In the aforementioned cases, we switched to the ipsilateral ulnar approach because there were contraindications for the contralateral forearm approach or this was considered not a good alternative. Furthermore, there were relative contraindications or patient’s preference against the femoral approach (as explained in Table 1).

Radial approach is a worldwide expanding method and is continuously evolving compared with the traditional femoral approach. New strategies are developed in order to expand the transradial approach in populations formerly considered as a contraindication (patients with negative Allen’s test, end-stage renal disease, previous coronary artery bypass grafting and implantation of two mammary arteries, need of catheters larger than 6Fr) and to improve the outcomes of patients treated transradially (minimize the conversion to femoral, reduce pain and spasm, reduce radial artery occlusion). Recently, we published the results of the transradial catheterization in patients with negative Allen’s test and the feasibility and safety of this strategy, were manifested3. Kedev et al reported the results of the transulnar approach and the feasibility and safety of this approach even in patients with previously occluded radial artery6. This was also confirmed by our results when we used the transulnar approach in patients with a harvested ipsilateral radial artery7. It seems that the rich collateral circulation of the arm, with the crucial role of the anterior interosseous artery, can provide sufficient blood supply for the hand, even in circumstances of temporary ipsilateral radial and ulnar artery malfunction, as it is the case in occlusion or sheath insertion.

Regarding hemostasis in patients having ipsilateral radial and ulnar artery cannulation, two devices were placed on the same wrist, and all patients had patent radial and ulnar arteries after closure device removal and no local ischemic complications. Similar hemostatic conditions have been described during the previously published ULTRA method5 for radial artery hemostasis. In these patients simultaneous compression of both radial (preferably with patent hemostasis) and ulnar arteries is performed, without symptoms or signs of hand ischemia, in order to augment radial artery flow and reduce the rates of occlusion.

It is prudent to keep in mind that ipsilateral radial and ulnar artery cannulation during the same approach should be reserved for patients: i) where contralateral radial or ulnar approach are not available, ii) when the estimated bleeding risk of the femoral approach is high (obesity, recent use of anticoagulants), and iii) only when performed by experienced radial operators.

The limitations of our study include the retrospective method of data collection, the small absolute number of patients finally managed with radial and ipsilateral ulnar artery cannulation and that all interventional cardiologists were dedicated radial operators with great experience in forearm arteries cannulation.


Radial and ipsilateral ulnar arteries cannulation during the same procedure is feasible and safe when applied in selected patients by experienced operators.

Conflict of interest

The authors declare that they have no conflict of interest.


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